Monday, September 30, 2019

The Ethics of Steroids in Professional Sports

Currently in professional sports, the use of steroids is one of the most highly debated and controversial topics. It seems that every day there is an athlete being suspended, fined, and even prosecuted for using these performance-enhancing drugs. In many cases, sports fans will condemn these athletes for their involvement in steroids. As I looked deeper into the subject I thought to myself, â€Å"what is so wrong with athletes trying to take their game to the next level?† Because ultimately, that’s what the real issue is here; its just professionals doing what they can to get ahead in their job and it seems to be perfectly ethical.One of the main arguments in the ethics of steroids in professional sports is that it is unhealthy to the body, which is completely true. The prolonged used of anabolic steroids can cause liver damage and contribute to hormone imbalances among other things; however, this does not make it unethical. Let’s not forget that these athletes a re playing sports that in many cases are already a danger to their bodies. When was the last time you heard of an athletes going to the hospital for the use of steroids? Yet everyday there is a case of a professional athlete tearing a muscle or incurring serious head injuries. Studies actually show that deaths from playing college and professional football are 50-100 times higher than the use of steroids. Just because somebody does something that may be harmful to their body, it doesn’t mean their wrong in doing so. For example, if a guy is hungry and decides to eat out at a fast food restaurant, is he pursuing something unethical? We all know the unhealthy effects fast food has on the body, but that doesn’t make it wrong. Adults should be able to make their own decisions when it comes to their personal well-being and if they decide to do something that may be harmful, then so be it.Protestors against steroids also claim that athletes using performance-enhancing drugs are a bad influence on our youth. Kids idolize athletes and if they see their favorite superstar using steroids, then they will want to also. I do see some truth in that and agree 100 percent that there is no place for steroids in child’s body. On the other hand I also contend that professional athletes have no obligation to live their lives conforming to a â€Å"role model† image. In Major League Baseball, the players are allowed to use chewing tobacco during games and it is clearly seen by the youth watching on TV. Also, In the National Hockey League, there is an immense amount of violence and fighting plays a big part in the sport. These examples are also bad influences on children, yet they are apart of the game and don’t seem to be getting banned anytime soon.As for the argument that steroids taint the game that so many love, I don’t see truth in this at all. There are constantly new techniques and technology being added in sports all for one purpose , to make the game better. Athletes dating back to the ancient times have been doing whatever they can to gain a competitive edge. The Greeks used to eat live bees for potency before matches and Mayans would take hallucinogens to numb the pain taken from their sport. So why is it unethical for an athlete to use steroids for this same purpose? Some say that athletes in the past didn’t have the luxury of steroids, so it eliminates the records and legacy of the past. But regardless, due to the revolutionary increases of technology, such as a newly designed baseball bat or a more aerodynamic track uniform, players are going to be better and these records are going to be broken.

Sunday, September 29, 2019

Different Aspects of Pain Essay

Pain is a subject to which all people can relate. There are many different types of pain, and people react to these pains in various ways. Pain is also caused from many different sources. It could be from grief, stress, or a significant event that occurs in one’s life. Pain is defined in the Dictionary as â€Å"mental or emotional suffering or torment.† The poetry of Robert Frost, James Langston Hughes, and Emily Dickinson all display different aspects of pain. Robert Lee Frost was born on March 26, 1874 in San Francisco, California where his father worked as a newspaper editor. This may have been where Robert was first exposed to the aspect of writing. Robert’s first published poem was in a school newspaper at the age of 16 where he wrote a poem on the subject of Cortez in Mexico. Although he attended Dartmouth for seven weeks and spent two years at Harvard, he never finished a college education with a degree. After he had gotten married, he worked as a schoolteacher, and during this period is when he spent time writing the majority of his poetry. After his teaching career, he moved to England to pursue getting his works published since his poetry was not accepted for publishing in America. His first two books of poems, A Boy’s Will and North of Boston, were published in England and then later in America due to the overwhelming popularity of them in England (Greenberg ix-x). Frost’s poem â€Å"Out, Out† tells a story of the tragic death of a boy due to a buzz saw. The title is an allusion to act five William Shakespeare’s Macbeth, where the main character, Macbeth, performs a soliloquy regarding the death of his wife: â€Å"Out, out, brief candle! / Life’s but a walking shadow, a poor player / That struts and frets his hour upon the stage / And then is heard no more. It is a tale / Told by an idiot, full of sound and fury, / Signifying nothing.† The allusion to Shakespeare in the title is appropriate to the subject matter because the soliloquy of Macbeth states that life is short, and inevitably will end. That is the message that Robert Frost is trying to convey in this poem. There are two different aspects of pain that appear in â€Å"Out, Out.† The first  one is the aspect of physical pain. This occurs when the buzz saw the boy is using, hits the boy’s hand and injures the hand severely. â€Å"As if to prove saws knew what supper meant, / Leaped out at the boy’s hand, / or seemed to leap — (Frost 522)† The boy then begins to feel the pain of what has just happened, the physical pain of his hand being severed by the buzz saw. The next type of pain that can be seen here is the psychological pain, caused by stress. As a result of the boy’s injury, he begins to fall into pieces about the whole matter (clarify this somehow. â€Å"fall into pieces† sounds a little ambiguous as well as clichà ©) . The poem says that the boy â€Å"half in appeal, but as if to keep / the life from spilling. Then the boy saw all — (Frost 522).† These two lines of the poem depict that the boy is old enough to understand what is going on with what is happening. His hand is injured beyond what the doctors can repair, and there is a high possibility of death because of what has just happened. The word ‘Life’ in this poem represents the blood that flowing from his hand. One can also see the apathy displayed by the rest of his family. Even though a member of the family has just died due to a tragic accident â€Å"Little–less–nothing!–and that ended it (Frost 522)† they show no pain of the loss of a family member. It is depicted in the last two lines of the poem, â€Å"No more to build on there. And they, since they / Were not the one dead, turned to their affairs (Frost 522).† This shows that they had no emotion to the event, and went on to what they were doing as if nothing had happened in the first place. The second piece of poetry presented is one by James Langston Hughes. James Langston Hughes was born February 1, 1902 in Joplin Missouri. He spent his early life living with his grandmother in Illinois. Hughes began to write poems, and also some short stories, while he was in high school. Hughes mentions that the primary influences to his writing are Paul Lawrence Dunbar, Carl Sandburg, and Walt Whitman. His first book of poetry, entitled The Weary Blues, was published in 1926, while he was in college. Hughes graduated from Lincoln University three years following the publication of his first book of poetry. The year following his college graduated, Hughes  won the Harmon gold medal for literature for the first novel that he wrote, Not Without Laughter. James Langston Hughes poem â€Å"The Negro Speaks of Rivers† was the first poem of his that was published. This poem was also set to music later on. It is written from the perspective of a man that ties together African and African-American history. Hughes does this by naming different rivers that are in Africa and also those that are in the United States. This is where the wordplay of Langston Hughes can be seen. The type of pain that is displayed in this poem is not very obvious, but it is more implied than directly stated. Seeing that this poems speaks of African and African-American History, the idea of the oppression that these people groups have gone through is something that can be inferred from what the poem says. Both of these people groups have gone through major oppression because of slavery, inequality, and the like. (while it is not obvious I would recommend trying to find a few lines that can possibly show the pain) The final poem presented here is a poem from Emily Dickinson. Emily Dickinson was born in the year 1830 in a family that was considered to be very wealthy for that time period. Her father ultimately led the family and was a religious man for the family. He read prayers and passages of scripture to all that lived in the household to maintain this. She attended the seminary for a year, but went home after that year due to a significant amount of unpleasant experiences. After Emily left school, she isolated herself from all activities and responsibilities that were outside of the household, and kept to herself most of the time. She spent a significant amount of time reading books. Because of the morals that her father had, there were not many things for her to choose from, as her father thought that most books that were available at the time might shake up her thinking patterns. She then settled to read the Bible, classical myths, and also the works of William Shakespeare. Because of this, a great amount of the poems that she wrote had allusion to her readings contained in them. Although there is very little that people know of Emily Dickinson’s outside life, but after reading the  poems that she has written, one can gain some access to the inside life in Emily Dickinson (Madden 1287). Emily Dickinson wrote nearly two thousand different poems in her lifetime (Madden 1288). Only but a few of these poems were intentionally published by her. Although Emily made her brother and sister promise to destroy all of her works following her death, her sister, Lavinia, could not gain the strength to destroy her sister Emily’s poetry. Not too far following her death in 1886, nine volumes of her works that were revised in wording, punctuation, structure, and rhyme were published. Unedited versions that were true to the original manuscript of Emily Dickinson where not published until 1955 (Madden 1288). Most of the poems of Emily Dickinson were her own personal laments that she did not intend for the public to ever see. â€Å"After A Great Pain, A Formal Feeling Comes† is an example of one of these extremely personal poems. During the time that this poem was written, Dickinson had just lost a very close friend. She was also beginning to dismiss the ideas of a career, starting a family, and making contact with anything or anyone that was outside of her own house. This whole poem directly deals with the pain of emotional loss that comes with the passing away of a person that is extremely close. Death was something that Dickinson never adjusted to, and it is displayed in this poem. She depicts how the feeling sits heavily and does not seem to go away very quickly â€Å"The Nerves sit ceremonious, like Tombs–(Dickinson 1291)† (Lundin 95). In the last two lines of the first stanza Dickinson says, â€Å"The stiff Heart questions what it He, that bore, / And Yesterday, or Centuries before? (Dickinson 1291)† Here she is reliving past pains and grief that have occurred in her life before the death of her friend. She also relives past painful moments in her life in the second stanza â€Å"The Feet, mechanical, go round (Dickinson 1291)† (Grabher 217). In the last stanza, Dickinson focuses on the present pain that is in her life. â€Å"This is the Hour of Lead– (Dickinson 1291)† refers to the passing of  Dickinson’s close friend. She then goes over the stages of how she moves on from these painful experiences: â€Å"As Freezing persons, recollect the Snow– / First–Chill–then Stupor–then the letting go– (Dickinson 1291)† The way that she ends this poems makes it appear as though she is trailing off into a land of thought to go dwell on what has just happened, to begin her process of recovery (Lundin 234). As one can see, many different aspects of pain have been discussed. Robert Frost’s â€Å"Out, Out† discussed physical pain due to an injury, and also the pain of stress due to that injury. James Langston Hughes implied the racial oppression of Africans and African-Americans that had gone before him in â€Å"The Negro Speaks of Rivers.† Emily Dickinson goes deep into her personal life and displays emotional pain with â€Å"After A Great Pain, A Formal Feeling Comes† by reminiscing on past grief and dealing with a new grief due to the death of a friend. As one reads through and analyzes these poems, one can see the way that pain is displayed in the midst of them and how each separate type affects people in different ways.

Saturday, September 28, 2019

Case for critical thinking: A flood of decisions Essay

1. What information sources (or potential information sources) could have been used to assist with the decision-making process for Wivenhoe Dam in this case? Potential information sources that could have been used to assist with the decision-making process for Wivenhoe Dam -SEQWater -Sought advice from Water Grid Manager -Water Commission -DERM (Department of Environmental Resource Management) Managerial decision-making Problem avoiders Problem solvers Problem seekers Approaches to decision making Classical decision model Behavioral decision model Judgmental decision model 2. With references to decision-making theory covered in the chapter, describe the type of managerial decision-making evident in this case, and the conditions under which decisions were made. Managerial Decision Making *Problem avoidably *Problem solvers *Problem seekers Decision conditions: *Certain environment *Risk environment *Uncertain environment 3. Evaluate the decisions made in the case in relation to the classical, behavioural and judgmental heuristics approaches to decision-making that are outlined in the chapter. Which model do you believe best describes the situation and subsequent decision-making process in this case? Justify your answer? Approaches to decision making ^Classical decision model ^Behavioral decision model ^Judgmental decision model Case decision *Classical decision model Problem: it was the flood that damage Brisbane and Ipswich Possible alternative: Not releasing flood waters. Consequently threatened stability of dam Optimizing decision: Release of flood waters being aware of potential damage. SWOT Analysis: Strengths: *New technology *They set priorities *Manage time Weakness: Lack of communication Misunderstanding Misconduct Problem solving Crisis Opportunities: *Professional engineer *Employment Threats: Natural disaster (climate change) Damage roads and homes. Conclusion People should make wise decision to save the lifes of the others.

Friday, September 27, 2019

Revision for Integration of Sources Essay Example | Topics and Well Written Essays - 750 words

Revision for Integration of Sources - Essay Example Below sentences with different sources derived from the article â€Å"Educating Young Adults about Sex.† The essay is part of my writings in English 1302. This is part of the original text under evaluation. From the sentences above, it is evident that there is a gap between the ideas in sentences and the citation. This is because the writer did not impact on source integration. One style of introducing sources may turn out to be monotonous. This is because the reader can prejudice the in suction of these citations. Writers should incorporate different source citation techniques acceptable in writing guidelines book. This will impact on the follow of ideas, follow of grammar, marrying of ideologies, and at the same time, readers will have an interest in reading the article (VanderMey 24). Phrases such as â€Å"From ... writings or book, it is evident that HIV is a fatal infection,† will add taste to the sentence. It will also prove to the reader that the writers are confident of their art work. Other suitable phrases are in reference to, in relation to, according to, from ... reading it is acceptable that..., also show that there is an admirable level of precision (Borchers 33). The writer of the original reference has admirable distribution of source citation. Many citations in a single sentence may lead to confliction of ideas. They can also lead to loss of meaning, when used by incompetent writers. It is appropriate for writers to proper make use of one source citation in each sentence. One can also depict that the sentence carrying the citation has no weight. In a paragraph, such sentence should create some emphasis, unlike other sentences. Form the above correction, it is noticeable that integration between the article and the source citation in crucial in all writing practices. As a reader read the sentences above, one will identify that there is a follow of ideals. Such follow proves to the readers that

Thursday, September 26, 2019

The Role of Women in Japan and Middle East Research Paper

The Role of Women in Japan and Middle East - Research Paper Example This essay will discuss the impact of globalization on different types of families in different societies and cultures. The terms ‘traditional’, ‘modern’ and ‘postmodern’ will be defined, elaborated upon and discussed on a continuum of change. Social change, in the face of globalization, will be discussed with relation to how cultures and families have grown or resisted the forces of globalization. We now turn to an exploration of the types of families in the world and follow with a concise description of the American family of today. Ranging from ‘traditional’ to ‘postmodern’, there are a variety of family forms in this world. For the theoretical purposes of this essay, a family will be defined as â€Å"two or more people who are in a relationship created by birth, marriage or choice.† (Roopnarine & Gielen 33). There are a multitude of family forms and family types across the globe and the global family is a social unit in a constant state of evolution. The ‘traditional’ family is a heterosexual, nuclear family headed by two parents in which the husband is the primary breadwinner and the wife is the homemaker. On the far left side of the continuum of change, the traditional nuclear family model is widespread across the globe and represents a traditional gendered division of labour, both within the house as well as outside of the home. In the Western world, the traditional model is becoming less and less viable as many families require the incomes of both parents. Wom en’s increased education and employment prospects have made the transition from the traditional model to the modern familial model more and more prevalent in modern Western society (Bossen 128-133; Roopnarine & Gielen 32-34). As with the traditional family, the ‘modern family’ is nuclear in the sense that it involves the cohabitation of two heterosexual partners but differs in that it involves dual

Literature review 8 Example | Topics and Well Written Essays - 8000 words

8 - Literature review Example By addressing issues such as of poverty, microfinance and its impact on and gender/power relations and women's empowerment, this study will attempt to inscribe itself into broader discourses and debates concerning equity and equality, gendered inequalities, power relations, women's economic and social empowerment as they are impacted by microfinance. Saudi Arabia is an undisguised, self-evident patriarchal state; this study aims at investigating the positive and negative implications microfinance bears on the Saudi female clients. By studying the initiative Bab Rizq Jameel (BRJ)1, and examining its underlying principles, rational accomplishments and goals, this study aims to examine its effects on power relations, decision-making and bargaining power in the household. This case study of microfinance in the kingdom of Saudi Arabia aspires to unfold an important and lacking dimension to the current debates surrounding gender and development in developing countries particularly in relat ion to debates surrounding gender equality2 vs. ... There have been continual debates on whether microfinance can be considered as a savior to poverty-stricken women from oppression and gendered inequalities or whether having access to micro-financial resources can empower women economically and socially. ‘Studies generally suggest the poorest seldom benefit from microcredit, while the middle and upper poor benefit the most (Maclsaac, 1997). This doesn’t apply to the case in Saudi Arabia because the BRJ scheme is a charity-based approach that is Shari’aa compliant (offering interest-free loans). There is a debate between whether microfinance can help promote gender-equality vs. gender equity. (See footnotes 2 & 3 for the difference) In the case of Saudi Arabia, gender equality would be an ideological scenario, given the religious, cultural and traditional framework in which there impoverished women operate. Gender equity is more of an attainable goal in this context. Furthermore, there are heated debates surroundin g the issue of microfinance being regarded a tool to facilitate women’s empowerment. A recent study in Bangladesh concluded that microfinance politically, ‘does not directly challenge any official views that subjugate women, nor that any hard evidence was found to prove that microcredit credit promotes empowerment or supports women’s liberation ’ (Faraizi et al., 2011). This study is particularly useful to this research because in many ways Saudi Arabia shares commonalities with the religious framework in Bangladesh; where Islamists in high positions of power officially subscribe to unequal rights for women. Whereby, any contrasting, disparate voices against the patriarchal dominant voice are silenced. (Faraizi et al., 2011) In the kingdom of

Wednesday, September 25, 2019

Network Protocol Essay Example | Topics and Well Written Essays - 4250 words

Network Protocol - Essay Example It is an admitted fact that computer technology has affected many parts of our life by playing a vital role. In addition, business organizations are adopting modern and innovative tools and technologies in order to survive in this ever-increasing competitive world. In fact, with the developments in information technologies, organizations are adopting the trend of building their IT infrastructure using already developed services rather than re-inventing the wheel. In view of the fact that it helps organizations reduce development costs and provide the system with greater adaptability as new services can be composed and existing services can be discarded in case of any change in business requirements or market conditions. In this regard, organizations are increasingly adopting Service Oriented Architecture (SOA) to build their IT infrastructure by dynamically composing loosely coupled services to perform their business operations. This research is aimed at exploring SOA and web service technology, focusing on its significance as compared to traditional distributed computing paradigms. In this paper, the significance of different protocols that form the basis of SOA and web services is also revealed and different frameworks and tools are discussed that provide the capabilities of development and integration. Keywords: Service-Oriented Architecture, XML, Web Service Description Language, Web services Introduction Service-oriented architectures (SOA) is a rising approach, promising, efficient and effective system that is loosely coupled, based on open standards, and is not bound to a special type of protocols. In this scenario, the operation of the organization, adopting SOA is run by invoking loosely coupled services often in an asynchronous or event driven style according to the requirements of the underlying business process (Papazoglou & Heuvel, 2007). Basically, the Web services have been very popular since 1999 and the most significant factor that forms the basis of success and popularity of web services is the truth that its backbone is XML (Suda, 2003). In addition, the Web Services work by defining web interfaces all the way through the usage of XML schema and a machine-readable specification called Web Services Description Language (WSDL) to describe the configuration of the input and output messages that are exchanged to invoke and consume the service (Wilkinson et al. , 2009). This paper will provide a brief description of SOA, web services and the advantages of web service technology over other traditional technologies. Basically, this research is aimed at exploring SOA and web service technology, focusing on its significance as compared to traditional distributed computing paradigms. In this paper, the importance of a wide variety of protocols that form the basis of SOA and web services is also revealed and different frameworks and tools are discussed that provide the capabilities of development and integration. Service Oriented Architecture (SOA) Service-oriented architecture (SOA) is an influential distributed computing architecture that facilitates a higher degree of abstraction in the development, deployment and operation of platform independent IT infrastructure. Additionally, the SOA involves the communication between service providers and service consumers for the consumption of hosted services. SOA provides with a scheme of architecting , implementing, installing, and administering the IT infrastructures, in which, business functionality is provided by reusable services with the help of interfaces which are defined separately from the service

Tuesday, September 24, 2019

Marketing Essay Example | Topics and Well Written Essays - 2500 words - 31

Marketing - Essay Example The museum should set its objectives so that it can move forward and always be referring to the objectives to enhance that it is moving on the right track. The objectives that will be set forth should be SMART, which translates to specific, measurable, realistic, and time bound. The following objectives are formulated using the guidelines of SMART; The strategies that will enhance the realization of the objectives set above include will be considered. Formulation of objectives is very important, which is based on identifying the best opportunities from the situational analysis. One of the key considerations is of setting the museums goals are that it should be consistent with the long term goals of the museum. When mentioning goals and objective, â€Å"they are a bit challenging but this is the charm it carries† (slater and Olson, 2001). The manner in which they are challenging is because they demand a lot of information to be gathered processed and evaluated. The external environment is usually uncontrollable, but using the normal PESTEL (political, economic, society, technology, environment, legal) it is and will be favorable for the marketing plan. The political environment of the company is favorable this is because of the mission statement that will make the government and the local council of Aberdeen to support t he project. The mission statement where it states that they will enhance conservation will be very much supported by the state government. The economy of the United Kingdom is one of the most stable economies of the world. This will help so much in the prices that will be set and help to raise more revenues to the Art gallery and Museum. Social factors are also favorable in the United Kingdom; the society of the country is diverse and very conservative this can be seen from the fact that the country still keeps the monarchy system of government. The fact that there is introduction of technology in the

Monday, September 23, 2019

Importance of Internal Relations Case Study Example | Topics and Well Written Essays - 250 words

Importance of Internal Relations - Case Study Example Generally it is the role of the school to form the best and most appropriate way of informing the public on their school system and the operations of the institution. The community which is part of the stakeholders has the massive role of bringing up and sustaining collaborative measures and means which lead to the success of the institutions and the eventual improvements of the institution. The result of the collaborative actions of the public and the school should yield students success and the improvement of the institution in all round perspective without compromising any aspect of an institution. The administrator of an institution should have the knowledge and understanding of building of consensus effectively and negotiation techniques, effective and good communication skills, he should believe in values and have an inclusion of all the members of the community. Most importantly the administration should ensure that all the visions and missions of the institution are effectively and clearly communicated to the parents, students, staff and the community members .The vision of the institution should be developed with among the community members and all the stakeholders. Generally the administrator is the head of the institution hence should nurture and promote the success of the learning process. This can be achieved through the advocating for effective learning mechanisms and friendly environment for the students and the staff to perform to their best potentials. Internal communication is very critical and determines the depiction of the staff and the students on how they perceive the ability of the institution to meet its goals and targets. Effective leads to the success of an institution due to the constant flow and sharing of information that will eventually lead to

Sunday, September 22, 2019

Three defining moments in Canadian history Essay Example for Free

Three defining moments in Canadian history Essay All throughout Canada in the 20th Century there have been numerous events, actions, and decisions that we call defining moments. Canada has been through many battles, hard-chosen decisions, and changes that have changed the way Canadians live today. The second battle of Ypres, the life on the home front in World War Two, and the invasion of D-day helped enrich Canada with their contributions to food, fashion, religion, education, business, and politics. All these moments were significant for Canada and changed the way we Canadians live today. OK, well go! With these words, General Elsenhower, commander-in-chief of the Allied Forces, announced the beginning of the long-awaited and -planned invasion of Europe. The Normandy beaches of northern France were selected as the site of invasion, because they were close to Britain and the invading army, supply ships, and reinforcements. A huge army gathered in the South of England. American troops numbering 1.25 million joined a similar number of British and Commonwealth troops, including 30,000 Canadians. Four thousand landing craft, 700 war ships, and 11,000 planes were ready. The Germans had 60 divisions in northern France and the Netherlands under the command of Field Marshall Rommel. In the spring of 1944, Allied bombers started attacking and destroying Nazi military sites in northern France. The idea was to soften the enemy defences. D-Day, Day of Deliverance, was fixed for June 5, 1944. But the invasion had to be postponed due to bad weather. At 2:00 a.m. on June 6, paratroopers were dropped to protect the landing forces. Seventy-five minutes later, 2000 bombers began to pound German defences on the beaches. At 5:30 a.m., the air raids were joined by the guns of the Allied warships. Then, at precisely 6:30 a.m., the first waves of Canadian, British, and American troops poured onto the beaches of France. This was Canadas largest military operation. Fourteen thousand soldiers were set to hit the beaches of France. The Royal Canadian Navy had 100 ships with 10,000 sailors in the operation. Flying overhead were 36 bomber squadrons of the RCAF. The Canadian soldiers landed at Juno Beach, and faced underwater obstacles, land mines, barbed wire, and heavy machine-gun fire from the Germans. At the end of the day, they had met their objectives, the only Allied force to do so that day. They had suffered 335 dead and 739 other casualties. Within a week, the Allies had 300,000 troops safely on  shore. Within a month, 1 million Allies had landed with 200,000 military vehicles. Though the Nazi forces fought hard, Hitler was now caught with war on two front, east and west. The second battle of Ypres (or modern Lepers) was one that completely changed the worlds perspective of Canada. Through courage and determination, the Canadian army was able to prove their strength. It all started in 1914 with the first battle of Ypres, in which the Germans had to reconsider their unsuccessful Alfred Von Schlieffen plan. They wanted to quickly eliminate the British and French, so they could finally attack Russia with full force. However, since they did not have enough time to constitute a new plan, the Germans decided to stick with the old one and use new warfare. By 1915, the second battle of Ypres was already under way, when the Germans decided to attack the potential weak spot in between the Canadian and French trenches. With the use of chlorine (or mustard) gas, the Germans were able to force the French army into retreating. The Canadians, however, used their combined thinking power to improvise a simple, effective gas mask, and fought back. The gas mask was composed of urine and a handkerchief, since the moisture could block the chlorine gas and allow for some oxygen to get in as well. When the German army moved out, they wore specialized uniforms and gas masks, and carried barbarous rifles such as the Bayonet. This gave them an overall inhuman and alien-like appearance, which was bound to scare anyone. However, this failed to intimidate the Canadians, as they simply went out with their own Bayonets and gas masks, and stalled the German army at their trenches. The other half of the army, however, had already punched holes in the French trenches and moved further into the battlefield. Thus, the Canadian army moved back and dispersed for a quick counter-attack. They filled in the gap left by the French, and pushed back the arrogant German army. At the same time, they fought the army that opposed their own trenches, and pushed them back even further. Since the German army never expected any resistance or counter-attack, they were completely vulnerable to the Canadian attack and had to retreat. When reinforcements from the French and British reserves arrived, they were surprised to find that the Canadians had in fact done the job of two armies. On that day, every Canadian soldier grew a few inches taller, and elevated  in honour, rank, reputation, skill, talent, strength, courage, and determination. For every victory, however, there is a price to pay, and for this great defensive victory, the number of casualties was paid in full. Of a maximum divisional strength of 18,000 that had started the battle, 5975 Canadians had become casualties, of whom over 1000 were fatal. The civilian population or activities of a country at war are called the home front. During WWII, the Canadian government proclaimed the War Measures Act and interned many Jewish, Italian, German, and Japanese Canadians, while sending 16,000 conscripted soldiers overseas. The War Measures Act was previously used in World War One against Ukrainian Canadians, but it was not merely as severe as in World War Two. The role of women grew closer to enemy grounds (such as actual navy, army, and air force positions), and once again, the rest took the jobs of men. Canadians grew dependant on the United States with NATO, NORAD, and Camp X. At times of war, the panicking people would rush to buy foods and supplies. Therefore, the Wartime Prices and Trade Board (WPTB) was established to control prices and supervise the distribution of food and other scarce goods. People needed ration cards to buy items such as gasoline, butter, sugar, meat, tea, and coffee. Rationing is when the government puts a limit to the amount every civilian can buy. As in WWI, total war meant that all industries, materials, and people were put to work for the war effort. The war basically affected everyone in Canada. In a very real sense, however, Canada also grew with the war. WWII helped Canada establish its place as an important middle power among world nations, while its GNP (Gross National Production) of goods (asbestos, aluminium, coal, manganese, chemicals, and paper) tripled, and all of its main industries expanded (thanks to the increased production of vital agricultural goods, such as wheat, flour, bacon, ham, eggs, canned meat, and fish). After the war, the Cuban Missile Crisis and the threat of a Third World War had people on the home front protesting about national security. The debate was mainly over Canada having nuclear warheads of its own, which most saw as a way to achieve national security, while others found it revolting and immoral. However, in 1963, when Lester B. Pearson of the Liberals became Prime Minister, all of the Bomarc missiles in Canada were armed with nuclear warheads. With the second battle of Ypres, the Germans persisted to use the Von Schlieffen plan, but with new chlorine gas warfare. Although the French retreated from their trenches, the brave Canadian soldiers stood their ground and improvised a gas mask composed of a handkerchief and urine. In doing so, they were able to stall the German forces at their trenches, and move back for a counter-attack at the Germans entering the French trenches. The surprised German forces could do nothing but retreat, and the Canadians gained international recognition for their selfless efforts. Of the 18,000 Allied soldiers present that day, 1,000 were dead and 5,957 were injured. On the home front, the War Measures Act was used to intern Jewish, Italian, German, and Japanese Canadians, while conscripting 16,000 soldiers to go overseas. Women grew closer to enemy lines with new positions in the army, navy, and air force. Canadian dependence on the United States grew with the establishment of the North American Air Defense Command, North Atlantic Treaty Organization, and Camp X. Total war industries and workers were put to work for the war effort. The long-awaited and -planned attack on Normandy occurred on D-day, 1944, with an almost never-ending wave of Allied troops, air raids, and warships. It was the largest military operation for Canadians who landed at Juno Beach, and faced underwater obstacles, land mines, and machine-gun fire from the Germans. However, at the end of the day, they were the only successful Allied troops with 335 dead and 739 injured. Nazis were now caught with heavy fire from both East and West. The second battle of Ypres in World War One, life on the home front in World War Two, and invasion of D-day helped Canada become the great nation it is today, a century later.

Saturday, September 21, 2019

advantages and disadvantages of vaccinations

advantages and disadvantages of vaccinations Introduction Vaccination or immunization is a means of providing specific protection against many common and damaging pathogens by stimulating an organisms immune system to either produce humoral antibodies against the pathogen (or toxins produced by the pathogen) or T cells that can provide cell-mediated immunity (Ghaffar and Haqqi, 2010). Though ancient scientists did mention about prevention of infectious diseases through immunisation, it was Edward Jenner who developed the first vaccine. The vaccine was developed against small pox in the year 1796. The next vaccine came up almost a century later by Louis Pasteur. The vaccine was anti-rabies vaccine and was first used in 1885. The development of anti-rabies vaccine kindled hope for prevention of other infectious diseases, leading to immense research and development of several other vaccines (Shah, Nitin and Kukrej, 2007). The term vaccination was coined by Edward Jenner. Vaccination is the method of causing immunity to a disease by administration of an antigenic material into the body. The term vaccination is used interchangeably with immunity, which is derived from the Greek word immune which means to be protected. Several vaccines have been developed which either prevent or ameliorate several infectious diseases. The first disease for which vaccine was developed is small pox. Infact, even before Edward Jenner developed a proper vaccine against small pox, people in India and China inoculated fluids taken from small pox vesicles of patients suffering from mild course of disease. Despite the marked usefulness of vaccination in the prevention of infectious diseases, vaccination is still a much debated topic and has several medical safety, ethical, political and religious implications. In this essay, vaccination, types of vaccines, implications of vaccination and novel vaccines will be discussed with reference to recent literature. Mechanism of action of vaccines Vaccines act by developing immunity to the particular disease by inducing the development of antibodies. There are basically 2 types of immunity, innate immunity and acquired immunity. Innate immunity develops after actual exposure to the disease organism. Acquired immunity develops after exposure to vaccination. Acquired immunity may be active or passive immunity. Active immunity is that immunity that develops following exposure to antigenic stimulus, while passive immunity develops after direct injection of antibodies in the form of either sera or immunoglobulins, inside the body. The type of immunity rendered by vaccination is active immunity. Passive immunity confers temporary protection. The antibodies are taken from individuals or animals who are already infected with the disease. Active immunity renders long term protection (Ghaffar and Haqqi, 2010). A pathogenic infectious agent induces disease and at the same time triggers the immune system of the host to develop antibodies against the disease. These antibodies help in the recovery of the host from the disease and continue to offer protection to subsequent infections from the same pathogen. This principle has been used for vaccination. Through vaccination, antigens which mimic the original pathogen of the respective disease are introduced into the body. The antigens only trigger the immune response, but do not cause the disease. The immune response may be cell-mediated or humoral, or even both, depending on which series of T helper lymphocytes are stimulated. Stimulation of Th1 series leads to lymphocytic response, while stimulation of Th2 series leads to humoral response. The timing of vaccine is based on several factors, the most important of which is the susceptibility of the disease, reactogenecity and presence of maternal antibodies. Thus, BCG and OPV vaccines are given at birth, because the child can get exposed to tuberculosis and polio at birth due to absence of maternal immunity and risk of susceptibility at this age. Similarly, vaccines against diphtheria, tetanus, pertussis, hemophilus influenza are given in early childhood for maximum reactogenecity and protection against the diseases (Shah, 2007). Many vaccines are given together and this makes sense because concurrent administration of more than one vaccine does not interfere with the take of one another. It is important to give atleast 4 weeks time before the administration of second dose of the same vaccine (Shah, 2007). Types of vaccines The antigens in vaccines may be either live organisms, modified exotoxins, subunits of organisms or whole inactivated organisms. There are basically two types of vaccine: live vaccines and inactivated vaccines. In live vaccines, the pathogen, either virus or bacteria is weakened or attenuated. They act by causing non-clinical and self-limiting disease, thus triggering the immune system and inducing immunity. On administration, the pathogens multiply in the host and trigger immune response. The pathogens do not cause any disease because they are attenuated. However, in immunocompromised patients, live vaccines can cause disease. One major advantage with live vaccines is that a single dose is sufficient to confer long-term immunity. Examples of live vaccines are oral polio vaccine, measles vaccine, mumps vaccine and yellow fever vaccine (Ghaffar and Haqqi, 2010). Inactivated vaccines consist of either killed pathogens, subunits of pathogens or toxins released by pathogens. The killed vaccines are made up of pathogens which are grown in suitable culture, subsequent to which the pathogens, either bacteria or virus are killed either thermally or chemically with formaldehyde. More often than not, the polysaccharide immunogenic antigen is binded chemically with a protein molecule, to enhance the immunogenecity of the vaccine. Inactivated vaccines have to be given in multiple doses. The immunity is for a short period. Hence boosters doses are essential. Examples of inactivated virus vaccines are, hepatitis A vaccine, inactivated polio vaccine and rabies vaccine. Inactivated bacterial vaccines are whole cell killed typhoid vaccine and pertussis vaccine. Viral subunit vaccine is HBsAg vaccine. Toxoid vaccines are tetanus and diphtheria vaccines. Capsular polysaccharide vaccines are hemophilus influenza, typhoid Vi, pneumococcal and meningococcal vacc ines. In these vaccines, though the pathogens are destroyed and are not able to undergo replications, the capsid proteins, which are antigens are recognized by the immune system of the vaccinees, causing an immune response (Ghaffar and Haqqi, 2010). Bacterial subunit vaccine is acellular pertussis vaccine. Sub-unit vaccines are those which use purified components of the cell wall to initiate immune response in the vaccinee. Some of the examples of such vaccines are meningococcus, pertussis, hemophilus and pneumococcus vaccines. An interesting vaccine worth discussing at this juncture is the hepatitis-B vaccine which is developed by purification of the antigenic proteins that are manufactured subsequent to expression from a gene that is cloned into a vector like yeast (Ghaffar and Haqqi, 2010). Polysaccharide vaccines are basically weak antigens that are T-independent and hence cause IgM responses without development of immunologic memory that is critical for stable and long-term imm unity. In such vaccines, the immunogenecity is enhanced by conjugating the antigens with other proteins like meningococcus, hemophilus and pneumococcus that are T-dependent and induce immulogic memory (Ghaffar and Haqqi, 2010). The type of vaccination needed for a specific disease depends on the pathogenesis of the disease. For example, pathogens like diphtheria and tetanus cause the disease by releasing certain toxins called exotoxins. In these cases, antibodies which neutralise and prevent the binding of the exotoxin to respective receptors on the target cells prevent the disease. Thus vaccines against diphtheria and tetanus are toxoids. On the other hand, other pathogens have other pathogeneses, and consequently, antibodies which either react directly with the pathogen or eliminate the pathogen through either intracellular killing, complement mediated lysis or phagocytosis are essential. Pathogens like protozoa, viruses and intracellular bacteria which harbor inside the cells cannot be accessed by the antibodies and in such diseases, cells harboring the pathogens need to be destroyed (Ghaffar and Haqqi, 2010). Immunity conferred by a particular vaccine may be either lifelong or may last for few months. Examples of former type of vaccines are mumps, rubella, measles, tuberculosis, small pox and yellow fever. Cholera vaccine confers immunity only for few months and hence may be used only during outbreaks. Vaccines like diphtheria, tetanus, pertussis, polio and hemophilus influenza are part of primary immunization and must be given between 2-3 months of age. Mumps, measles and rubella vaccines must be given between 13- 15 months (Shah et al, 2007). Adjuvants Adjuvants are those chemicals which are added in the vaccine to enhance the immunogenecity of the vaccines. The most widely used adjuvants are aluminum salts, which are used in DPT. Other adjuvants which are in experimental stage include Freuds complete and incomplete adjuvants, certain oligonucleotides and some synthetic polymers. Certain bacteria also act as adjuvants and examples are Nocardia and BCG. Adjuvants increase immunogenecity by recognizing TOLL-like receptors, leading to activation of mononuclear phagocytes and induction of certain cytokines which enhance Th1 and Th2 responses (Ghaffar and Haqqi, 2010). Prophylactic and therapeutic immunisation Most of the vaccines are given as a prophylactic measures against their respective diseases, in the sense, the vaccines are given prior to exposure to the disease pathogen. In case of rabies and tetanus, the vaccination is given after exposure to the pathogen and this is known as post-exposure immunization. In some situations like tetanus, which has very short incubation period, both active and passive immunisation may be necessary post-exposure (Shah, 2007). Strains used Only particular strains are used for the development of any vaccine. Danish 1331 and Copenhagen are the commonly used strains in the BCG vaccine. Both are strains of mycobacterium bovis. In each 0.1ml, 0.1- 0.4 million live viable bacilli are present. Each vial of OPV vaccine contains more than one million inactivated viruses 1,2 and 3. Measles vaccine is derived from live attenuated Edmonston Zagreb strain that is grown in the human diploid cell culture. MMR vaccine vaccine contains 1000 TCID50 of measles, 5000 TCID50 of mumps and 1000 TCID50 of rubella virus . There are several strains from which measles vaccine is developed and they are Edmonston Zagreb, Schwarz, Moraten and Edmonston B strains. The strains are grown in human diploid cell culture and live attenuated viruses are used to prepare the vaccine. Of these, Edmonston Zagreb strain is the most commonly used strain. The mumps strains used are Urabe AM9, Leningrad-Zagreb, RIT 4385 or Jerryl Lynn. The efficacy between various strains is similar. The strains are grown in chick embryo or human diploid cell cultures. For preparing the rubella vaccine, the strain used is RA 27/3 vaccine strain. The virus is grown in human diploid or chick embryo cell cultures. Live attenuated form of the virus is used for preparation of the vaccine (Shah, 2007). Market availability BCG vaccines are available in multi-dose dark colored ampoules. Single dose vaccine is not available. The vials are available as 10-dose vial and 20 dose vial. The 10 dose vial has to be reconstituted with 0.5 ml of normal saline and the 20 dose vial has to be reconstituted with 1ml sodium chloride solution (Shah, 2007). Storage Storage again, depends on the type of vaccine. Constituents of BCG vaccine are freeze-dried and can be stored at temperatures between 2-80 degree centigrade for one year. The preparation is vacuum sealed. Hence the ampoule must be opened carefully after gradual filing to avoid sudden entry of air and spillage of the contents. Reconstitution is done using normal saline. The vaccine has no preservative and thus the chances of bacterial contamination are high. Hence after reconstitution, the vaccine must be used within 4 hours and the left over vaccine must be discarded. Until those 4 hours, the vaccine has to be stored between 2- 8 degree centigrade. Oral polio vaccine contains stabilising agent magnesium sulphate and hence is stable after refrigeration. At state and district levels, the polio vaccine stocks must be stored at -200 degree centigrade. In clinics, it must be stored in the freezer. While transferring the vaccine to an outreach facility, the vaccine must be carried in prope r vaccine carriers loaded with ice packs to maintain temperature between 2- 80 degree centigrade. DPT vaccine has to be stored between 2-8 degree centigrade. The vaccine should never be frozen and any vial accidentally frozen must be discarded. Measles vaccine can either be frozen or stored in refrigerator compartment (Shah, 2007). Shelf life Shelf life varies from vaccine to vaccine. While some vaccines can be stored for several years, some others can be stored only for few months. For BCG, when stored under recommended temperatures in dark place, the shelf life is 24 months. Measles vaccine is supplied as freeze-dried and the shelf-life is 1-2 years or even more (Shah, 2007). Reconstitution While some vaccines like DPT and typhoid are ready-to-use vaccines, others like BCG, measles and hemophilus influenza vaccines are freeze dried need to be reconstituted with appropriate solutions. BCG vaccine has to be reconstituted with sodium chloride solution provided by the manufacturers. measles vaccine must be reconstituted with sterile water. The vaccine does not have any preservative and hence strict asepsis must be maintained while diluting and aspirating contents. Reconstituted vaccine must not be stored (Shah, 2007). Administration Site and mode of administration depends on the vaccine. For BCG, the vaccine can be given anywhere. However, the recommended site is the convex aspect of the left shoulder for the purpose of easy visualization of the scar. The most preferred site of injection is the site at which the deltoid inserts into the humerus. Injection at sites higher than this level on the arm are likely to develop keloid (CDC, 2009). Oral polio vaccine is administered orally. The principle behind oral vaccination is that high gut immunity levels prevent transmission of the wild or pathogenic polio viruses. DPT, Hemophilus influenza, inactivated polio , hepatitis A, hepatitis B, typhoid, and other such vaccine shave to be given intramuscularly and measles, mumps, rubella and varicella vaccines need to be given subcutaneously. The seroconversion rates of the oral polio vaccine are variable. For polio viruses type- 1, 2 and 3, the seroconversion rates after one dose of vaccine are 73%, 90% and 70%. Hence multiple doses are recommended to achive seroconversion of 90- 95 percent for all the 3 types of vaccine (Shah, 2007). Advantages of vaccination The advantages of vaccines are innumerous and hence all countries in the world have adopted vaccination in their public health policy. infact, vaccination is the best means of prevention of certain infectious disease, especially in new borns, infants and childrens who are vulnerable to certain diseases. In many cases, even if the vaccinee develops the disease for which he or she is vaccinated, the course of the disease is usally mild and recovery is fast. Attenuated vaccines trigger all phases of immune system and confer more stable immunity. Most live attenuated vaccines need no boosters. they are cheap and immunity develops quickly. The drugs are easy to transport. Some live vaccines like oral polio vaccine are easy to administer, can be given orally (Shah, 2007). Vaccines are useful not only to prevent disease, but also to eradicate the disease from the globe. Small pox, a deadly poxy disease was eradicated from the world only through vaccination. Currently, polio is on the verge of eradication because of oral polio vaccines and inactivated polio vaccine. However, there is ongoing debate about the continuing use of these vaccines with respect to community protection, as against individual protection. This debate arises in the wake of rising cases of paralytic poliomyelitis and vaccine derived polioviruses with oral polio vaccine (Thacker and Shendurnikar, 2003). Researchers are under the opinion that once poliovirus is eradicated, vaccine derived poliomyelitis will surge if oral polio vaccine administration is continued. To gaurd the development of this problem, inactivated polio vaccine which is administered in the form of injection is being introduced even in developing and underdeveloped countries (Shah, 2007). Bacillus Calmette Guerin vaccine or BCG vaccine is a vaccine against tuberculosis that was first developed in 1921 by Albert Calmette, a French microbiologist and Camille Guerin, a veterinary surgeon. Currently, BCG is the only vaccine against tuberculosis. The mechanism of immunity induced by this vaccine is cell-mediated immunity. The protective effect of this vaccine is not very good, especially for pulmonary tuberculosis ( Vaccines are a of immense economic value in the health care system and this is evident from the cost-benefit ratios (1:10) of poliomyelitis and measles (Mason et al, 2002). However, in developing and underdeveloped countries many people do not have the access to many vaccines due to lack of infrastructure, coordinated health policies and cost factor. Disadvantages of vaccination Vaccination is associated with many side effects. However the benefits of vaccination outweigh the disadvantages of vaccination. The safety of vaccines is always a disputed aspect, expecially by critics. However, vaccines are selected basically based on the necessity, safety and efficacy and they licensed only after undergoing 3 phases of trials. The first phase is on human volunteers for safety and tolerance aspects. The second trial tests immune response and safety in human volunteers and the third trial checks for field efficacy nd safety. After these trials, potency, purity and sterility tests are performed by both the manufacturer and the Drug controller of the country and only when these are satisfactory is the vaccine released into market. The efficacy of certain vaccines like BCG is doubted. While many studies have shown this vaccine to be efficacious, promoting its ised in Asian and African countries, the vaccine is not recommended for routine use in the United States because of the doubts casted on the benefits of the vaccine through some studies (CDC, 2009). Improper manufacturing of inactivated vaccines can result in infections due to intact pathogens. Booster doses are essential for inactivated vaccines because the antigens cannot reproduce and thus periodic reinforcement of immune response is mandatory (Ghaffar and Haqqi, 2010). Some previous studies published a causal relationship betwen measles-mumps-rubella vaccine and autism. However, the Institute of Medicine nd Immunisation Safety Review Committee (2004) investigated the relationship and rejected the causal relationship. Though vaccination against varicella is highly efficacious, many experts do not recommend the vaccine because naturally acquired immunity offers protection life long and prevents adult chicken more which is more severe than childhood chicken pox. Infact, some studies have shown that iniversant infant vaccination of chicken pox will cause a surge in chicken pox in adulthoos and during pregnancy. Based on these studies, experts are of the opinion that though chicken pox vaccination prevents economic loss due to loss of work time, health care costs may arise (Ferson, 1995). Some experts are of the opinion that the shift of surge in cases towards adulthood and oldage can be minimised by administering the vaccine in 2-3 doses, instead of single dose (Senterre, 2004). In some countries, a new combination vaccine consisting of vaccines against measles, mumps, rubella and varicella has been developed. While the argument as to whether universal vaccination against varicella continues, this co mbination vaccine is viewed from a critical point because of increased risk of febrile seizures. (Klein et al, 2010). Vaccine against Japanese Encephalitis, a zoonotic viral disease is widely used in countries in Asia. The vaccine is an inactivated vaccine developed from infected brain tissue of mouse. This vaccine is expensive and needs to be administered in 2-3 doses. Even booster dose is required for this vaccine. However the vaccine is associated with adverse reactions in significant number of people. In China and other regions like Korea, a cheap vaccine is used with strain SA 14- 14- 2. This vaccine is not associted with significant allergic reactions. Though the vaccine has been deemed effective, there are not many trials to support the safe and efficient use of this vaccine (Plesner, 2003). Some vaccines are very costly. For example, the vaccines against HPV virus, for the prevention of cervical cancer are around 100US dollars. The efficacy of the vaccine is 70 percent and hence screening for cervical cancer needs to be done even despite vaccination. The vaccine has to be given in 3 doses and many people cannot afford the price (Madrid-Madrina, 2009). Live attenuated vaccines are difficult to transport and have a risk of undergoing secondary mutation which can cause virulence. Also, these vaccines can cause disease in immunosuppressed persons, which makes them useless in those with immunocompromise. It is for these reasons that live oral polio virus vaccine, also known as the Sabin vaccine is being gradually replaced by inactivated polio vaccine or Salk vaccine. Almost all vaccines have some adverse effects. The most common adverse effect is soreness and redness at the site of injection. other adverse effects include fever, malaise, disconfort, allergic reaction or even neurological problems. The type of side effect depends on the vaccine. In BCG, adverse reaction in the form of papule and ulcer formation is an indication of successful vaccine administration. Soon after the vaccine is administered a wheal of atleast 5 mm develops which is an indication that the vaccine was administered in the most appropriate manner. After about 2-3 weeks, a small papule develops at the site of injection which gradually increases in size to about 4- 8mm by the end of 5-6 weeks. After about 6 weeks, the papule ruptures and an ulcer develops. This ulcer heals slowly and develops a scar after 6- 12 weeks. Other undesirable adverse reactions can occur in 1-10 percent cases. They are delayed healing of ulcer, lymphangitis, enlargement of ipsilateral cervical and axillary lymph nodes, abscess formation, osteomyelitis and rarely disseminated BCG vaccination. After DPT administration, side effects in noted in more than 40 percent of vaccinees. The most common adverse effect noted is pain and redness at the site of injection. The pain may be so severe that the child may not be able to move the limb and walk. Induration and swelling may also be present. Fever is also very common. It may last for 24- 72 hours and responds well to paracetamol. All children who have been administered this vaccine must receive paracetamol whether there is fever or not, for control of pain. Other systemic side effects include vomiting, anorexia, irritability, lassitude and excessive crying.The side effects are due to pertussis vaccine. Rarely, seizures can occur after administration of the vaccine. For vaccines like measles and varicella, rash and fever many occur (Shah, 2007). Some adverse effects can be nasty. For example, Swine flu vaccine is associated with Guillian barre syndrome, anaphylactic shock, vasculitis, paralysis and even death and this aspect is preventing many individuals from taking the vaccine.(Menzies et al, 2008). Pneumococcal vaccine can rarely can anaphylactic shock or even convulsions (Haber et al, 2009). Thus vaccination is associated with several risks and prior to administration of vaccines, the risks and benefits must be ascertained. Combination vaccines 2 ore more vaccines can be either given together at the same time. Currently, two or more vaccines are administered through the same injection. The combination depends on the vaccine and the manufacturers criteria. For several years, diphtheria, tetanus and pertussis were given as combination vaccine, known as DPT. Similarly measles, mumps and rubella are also available as combination vaccines. other recent combination vaccines include hepatitis A and B vaccines, DPT with hemophilus influenza and inactivated polio vaccine, etc. Combination vaccines are safe and reduce the number of injections that need to be given to the child. They do not decrease the efficacy of vaccination. They increase the compliance to vaccination (Shah, 2007). Novel vaccines Some novel vaccines have been developed and are under trial in the wake of debate between advantages and disadvantages of current vaccines available. Some of the important ones are DNA vaccines, immunodominant peptides and anti-idiotype molecules. of recent interest in the field of vaccination are plant-vaccines, which are erived from plants and can be administered orally or through oral mucosa (WHO, 2010). The vaccines derived thus are expected to be cheap with minimal side effects. research in plant vaccines is a result of revolution in proteomics and genomics, and greater understanding of the molecular basis of infectious diseases and advances in modern biotechnology. Edible plant vaccines employ a new strategy of combining plant biology with medical science. Research has shown that some variants of tobacco express hepatitis B surface antigen and streptomutans surface protein and infact the torch of research in plant-derived vaccines is taken from here. Novel vaccines have only su b-units of the pathogen and hence do not cause any virulence even in immunosuppressed patients. other than tobacco, other plants which are potential sources of vaccines are tomato, banana, alfalfa, legumes and certain cereals (Refer figure and tables below). Some research has pointed to the role of oral transgenic plant-derived vaccines in the prevention of diarrhoeal diseases by some pathogens like norovirus, enterotoxigenic Escherichia coli and cholera (Tacket, 2004). Plant-derived vaccines have several advantages. Besides lower cost of vaccination, another major advantages of the vaccines are that they are administered orally and hence the need for injection equipment is not needed. This decreases the risks associated with injections like unsafe injection, poor sterilization, misuse and reuse. The vaccines will need less rigorous formulations for manufacture and supply unlike injections. Another major advantage of plant-derived vaccines is heat stability which avoids the maintena nce of expensive cold-chains, and allows easy portability of the vaccine. Since most of the plant-derived vaccines are effective mucosally, it is an advantage because most infections are acquired through mucosa and mucosal immunity prevents entry of the pathogens into the host. Plant-derived vaccines can be given as combination vaccines. Plant derived vaccines can be given even for diseases not covered under regular vaccination like sexually transmitted diseases, dengue hookworm and HIV. The development of plant-derived vaccines is yet in cocoon stage due to return of investment doubts, uncertain licentures, limited human trials and lack of expertise (Arzten, 2002). Fig.1. Plant derived vaccine development strategy (Das, 2009). Table 1. Antigens produced in transgenic plants (Das, 2009) Protein Plant Hepatitis B surface antigen Rabies virus glycoprotein Norwalk virus capsid protein E.coliheat-labile enterotoxin B subunit Cholera toxin B subunit Mouse glutamate decarboxylase VP1 protein of foot and mouth disease virus Insulin Glycoprotein swine-transmissible gastroenteritis cornavirus Tobacco Tomato Tobacco Potato Potato, tobacco Potato Arabidopsis Potato Arabidopsis Table-2. Transient production of antigens in plants after infection with plant viruses expressing a recombinant gene (Das, 2009) Protein  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Plant  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Carrier Influenza antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Tobacco  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     TMV Murine zona pellucida antigen  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Tobacco  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  TMV Rabies antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Spinach  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   AFMV HIV-1 antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  AFMV Mink enteritis virus antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Black eyed bean  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   CPMV Colon cancer antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Tobacco  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   TMV Table-3 Antibodies and antibody fragments produced in transgenic plants (Das, 2009) Antibody  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Plant IgG (k)  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Transition stage analog  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco IgM (ÃŽÂ »)  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   NP(4-hydroxy-3-nitrophenyl)  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  acetyl hapten Single domain (dAb)  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Substance P  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Tobacco Single chain Fv  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Phytochrome  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Tobacco Single chain Fv  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Artichoke mottled virus  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  coat protein Fab; IgG (k)     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Human creatin kinase  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Arabidopsis IgG (k)  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Fungal cutinase  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco IgG (k) and SIgG/A  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   S. mutagens adhesin  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Tobacco hybrid Single chain Fv  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Abscisic acid  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco Single chain Fv  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Nematode antigen  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco Single chain Fv  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  ÃƒÅ½Ã‚ ²-glucuronidase  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Tobacco   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  ÃƒÅ½Ã‚ ²-1,4 endoglucanase  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Single chain  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Atrazin, Paraquat  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Tobacco antibody fragment  Ã‚  Ã‚   IgG  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Glycoprotein B of  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Soybean   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Herpes simplex virus  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Conclusion

Friday, September 20, 2019

Racial Stereotypes In Disney Movies

Racial Stereotypes In Disney Movies The objective of Disney films was to transport its viewers to a magical realm of enchantment and endless possibility. Disney offered a supposed alternate paradigm in which there was the promise of a Happily Ever After. It aimed at appealing to audiences young and old and hoped to find universal viewership. Walt Disney once stated that Of all of our inventions for mass communication, pictures still speak the most universally understood language. And although it did reach audiences far and wide, for a young Indian girl watching The 1937 Disney adaptation of Snow White and The Seven Dwarfs, it gave her very little to identify with or relate to. Snow White, the first on-screen Disney Princess was rendered With lips as red as rubies and skin as fair as snow. Blatantly epitomising Western ideas of femininity and beauty, films like Snow White alienated the Non-western viewer. They created a fantasy that was centred on fixed archetypes of beauty and desirability which catered to the white, western population and had no room for anybody else. Eventually, the industry was criticised for its focus on a singular ethos and restriction to the First World. Consequently, the last decade of the 20th century saw Walt Disney Pictures release films that were now aimed at broadening its cultural spectrum. Alladin, debuted as Disneys first attempt to explore a different cultural terrain. Released in 1992, it was later followed by other culture specific films like Mulan and Pocahontas which opened in cinemas in 1998 and 1995 respectively. These films signalled a distinct departure from films that were pivoted around Western protagonists and their lived experiences. Although this new brand of films hoped to establish a sense of cultural inclusivity by venturing beyond the Western World, what became clearly evident in the process was a heavy dependence on racial stereotypes and caricatured depictions of culture. Elena Di Giovanni, in her essay Disney Films: Reflections of the Other and the Self, states that Disneys selection of certain cultures which it chose to portray, was not a choice that was arbitrary and unplanned. According to Di Giovanni, the reasons for selecting these cultures can be ascribed to precise cultural and ideological strategies. The cultures depicted in these films are either conventionally considered to be somehow inferior if juxtaposed with modern Western Civilisations and to the narrating American culture in particular, as suggested by the Saudi Arabian-born scholar Ziauddin Sardar. Edward Said was one of the first scholars to examine the complex relationship between the Orient and the Occident, one that he found to be a relationship of power, of domination of varying degrees of a complex hegemony In his 1978 publication of Orientalism, Said One of the first scholars to give a sharp account of these biased cultural encounters was Edward Said in Orientalisrn(1978). Even though primarily concerned with tracing the history of the Orientalist attitude by the West in literature, Said does not fail to consider the importance of new technologies and the media in the proliferation of this unjust tradition: One aspect of the electronic, post-modern world is that there has been a reinforcement of the stereotypes by which the Orient is viewed. Television, films, and all the medias resources have forced information into more and more standardized moulds. More recently, Ziauddin Sardar has echoed similar ideas in his 1999 publication of Orientalism, a book he writes, as assort of tribute to Saids work, therefore titling it the same. The main interest of Sardars book, whose approach is even harsher than Saids, lies in his detailed reflections upon the new, modern ways by which the Orientalist attitude manifests itself and is still spreading nowadays. By way of introduction to his work, Sardar declares that even though the project of Orientalism has way passed its sell by date, it is colonizing new territories, such new territories being related to the new geographies which are shaped and controlled by contemporary means of mass cornmunication like the cinema. A whole chapter of Sardars work is devoted to Orientalism in films, where the author sets out to explore the treatment and manipulation of other cultures within the discourse of cinema, across different genres, including cartoons, and where he makes ample reference to the Americ an hegemonic control of the cinematic medium. Sardar states that otherness is generally treated as a pattern book from which strands can be taken to draw up cultural representations which serve the purpose of entertaining audiences while reinforcing, by contrast, the superiority of the narrating culture. Thus, the the commodification of culture takes place whereby visual and verbal elements belonging to a distant world are taken and made suitable for smooth reception within more powerful socio-cultural settings. Aladdin, which was based on the Arab folktale of Aladdin and the magic lamp from One Thousand and One Nights, became the most successful films of 1992, grossing over $502 million worldwide. However, almost instantly, it was met with criticism from the American-Arab Anti-Discrimination Committee. The movie quite literally translated into an Orientalist fantasy. With glaringly distorted depictions of Arab culture, and a few pointedly offensive remarks, the movie has gone down in history as one of Disneys most controversial films. The film, which is set in the fictitious kingdom of Agrabah, introduces an ensemble cast of characters: Aladdin, a young street urchin, Jasmine, a jaded princess, Jafar, an avaricious minister of Court and Genie, the ebullient prisoner of the lamp. Although the film seems to focus on the characters as individuals, it is difficult to dismiss the overall denouncement of Arab culture, as is evident in the treatment and presentation of Arab society in the film. The vilification of Arab men in the film can be observed quite clearly through their portrayal as thugs, sorcerers, pick-pockets or beggars. Their physical attributes also seem to echo the cultural bias, with their descriptions coloured by thick lips, missing teeth, heavy, menacing brows and hooked noses. However, what is interesting to observe, is the decidedly different treatment afforded to the central protagonists. Both the hero and heroine are presented as almost exact counterparts to the white, suburban youth of the west. Aladdin seems fairly content in disinheriting his Arabian heritage, as he is cleverly christened Al, and exhibits American mannerisms through his style of speaking in the film. In the same vein, the character of Jasmine is equally americanised. Jasmine, though sporting dark flowing hair and with darker skin than her counterpart princesses in earlier films, still retains blue eyes. Though Jasmine must reflect an Arabian image, the films producers seem to find i t necessary to leave at least a vestige of tangibility that Western audiences can relate to. What one is left to ponder is whether these characters would have appealed to western audiences, had they not been endowed with these traits? This example recalls Saids own observations on Orientalist attitudes. Bring in said here. And Elena di Giovanni A whole new world then move to another song that was in fact more noteworthy. Most noteworthy, however is the opening sequence of the film, which was later revised due to harsh criticism and protests. Aladdin opens with the expository song Arabian Nights which includes the lyrics PEDDLER: Oh I come from a land From a faraway place Where the caravan camels roam Where they cut off your ear If they dont like your face Its barbaric, but hey, its home The blatantly offensive final line had to be eliminated from the home video version of the film as a consequence of the numerous protests the Disney Company received after international release. However, all the other subtle and indirect hints at the American cultures position of supremacy over the narrated Other, which is deliberately kept ambiguous and undefined in historical-geographical terms, remain untouched, and continue to carefully shape the viewers perception. One of these subtle instances in the movie can be seen in the same opening sequence. The first words which are uttered by the peddler contain an unmistakable, conventional reference to the culture portrayed: PEDDLER: Ah, Salaam and good evening to you worthy friends. The worldwide-known Arabic greeting is, however, immediately followed by good evening, as if to compensate even for the faintest sense of estrangement the viewer might feel upon hearing salaam. Orientalist preconceptions find their way into the Disney adaptation of the Chinese legend of Hua Mulan. Walt Disney Pictures released Mulan in June, 1998 and it was the thirty sixth animated feature in the Walt Disney Animated Classics. Mulan, which was once again infused with orientalist imagining of culture, uses a host of long-established, worldwide-known stereotypes on the visual as well as verbal levels. As Elina Di Giovanni points out, cultural metonymies are very often related to specific domains such as food, which provides universally identifiable socio-cultural references and ensures easy, if strongly stereotyped identification of different nations and peoples. In the case of verbal stereotypes, references to other cultures clichà ©d words and expressions tend to draw from common categories such as greetings, exclamations and titles. Greetings and exclamations, though not necessarily connected to the stereotyping of cultures, can nonetheless be frequently used to support cultural representations as they ensure simple and immediate identification. In the opening sequence of Mulan, the 1998 film which portrays the Chinese culture at the time of the invasions by the Huns, the visual and verbal cultural stereotypes employed do not contain any derogatory reference, but they are equally highly conventional. An instance of this can be seen in the portrayal and dialogue of the emperor of China who, incidentally, is always shown with the image of a golden dragon at his back to address his army generals in a situation of emergency. He is shown to exhibit a typical trait which is often associated with the Chinese culture, using words of wisdom to describe the fate of his country: EMPEROR: single grain of rice can tip the scale Moreover, one can note that the reference to the most popular element of the Chinese culinary tradition does not appear by coincidence in the emperors line. The shot which immediately follows features a large bowl of rice in the foreground with a pair of chopsticks lazily picking at the rice. This image is used in the film to introduce the protagonist herself, who will be very slowly revealed to the audience starting from her hand holding the chopsticks. But even more noteworthy, is that fact that the bowl of rice which alluded to in the beginning by the Emperor, and used in the introducing of the protagonist, Mulan is then later appropriated to serve American cultural interests by replacing the contents of the bowl(rice), with porridge and rashers of bacon and fried eggs, which make up Mulans breakfast. The bowl which contained rice in the opening scene has been deprived of its typical, if also highly conventional, Chinese content to be replaced by what looks more familiar to the American viewers, although totally remote from the eating habits of Chinese soldiers. Moving from visual to verbal examples, the use of language is an obvious vehicle for further consolidating the presence of American culture. It is worth pointing out that all the main characters in the films, although belonging to distant and exotic worlds, speak with perfect American accents. Moreover, they are very often characterized by the use of non-standard, colloquial or regional varieties of American English. This is the case of the dragon Mushu in Mulan, whose dialogue is generously punctuated with contemporary, informal American expressions. Similarly, in Aladdin, the most striking, informal and modem use of Ameriean English is to be found in the lines uttered by the genie of the lamp, appearing in different guises and often mimicking famous American personalities. His lines are filled with colloquial expressions as well as references to the contemporary American world. Pocahontas, which opened in cinemas in the year 1995, presented a thoroughly revised picture of a historical figure, appropriated suitably to appeal to western audiences. Modelled on the historical Native American figure ,Matoaka, who is more popularly known by the nickname Pocahontas, the film revamps and restructures the story of Pocahontas and showcases it as a tale where a culture under siege by British Colonialism, ends up being rescued by the White Messiah. The film clearly distorts historical facts and produces a tale that is made palatable to western audiences, with the White Settler rescuing the native tribe from a terrible fate, which, interestingly enough, would have been executed by his fellow men. The movie Pocahontas deviates from the true historical story in many ways. The most significant deviation is Pocahontas age and the nature of her relationship with John Smith. In the movie, Pocahontas is portrayed as a twenty year old woman who falls in love with John Smith, and he with her. From what we know of the historical record, she [Pocahontas] was a child when they met, probably between 12 and 14, and Smith was about 27, states Thomasina Jordan, the head of the Virginia Council on Indians, and herself a Wampanoag Native-American. However, it is not just her age that has been altered in the film version. Even her physical appearance is rendered far from factual. The on-screen Pocahontas is designed to be a tall, attractive figure, with dark, flowing hair and sharp features. This depiction in the film has been clearly designed to cater to the male fantasy of the young, exotic woman. Moulded from the Orientalist perspective, she is seen as the enigmatic princess, who captivates the young John Smith with her gentle spirit and exotic beauty. Moreover, the relationship between John Smith and Pocahontas, was that of a young girl and an older man. The relationship that the two share in the movie is entirely fictitious and completely inaccurate. Another deviation is John Smiths attitude towards the Native Americans. In the movie, Smith defends the Native-Americans, and dons the mantle of the White Messiah. Abandoning his fellow men, Smith advocates the legitimate right of the natives to possess their own land. He states that the British are the intruders and have no authority to colonise and usurp the land of the natives. This heroism, is however absent in factual accounts of the story. In reality, Smith believed that the English had a right to the land and he was not an advocate for the Native-Americans. Disney also distorts the facts about Governor James Ratcliffe. In the movie they portray him as a villainous character. At the end of the movie he tries to shoot Chief Powatan, but shoots John Smith instead. After he does this, his own men make him a prisoner and send him back to England. However, this is not confirmed in the historical account. Thus, it is evident, that even through Disneys attempt to create a more panoramic view of Society and the world, by retelling tales rooted in different socio-cultutal contexts, it is unable to rid itself of omniscient Western ideals which dictate the ways in which Non-western cultures are received. The non-western cultures can only be understood when either juxtaposed with western traditions or appropriated to appeal to a western audience. The appeal of a non-white prince must be countered with distinctly Americanised mannerisms. Tales from the East seem only to be tangible if they propagate long standing stereotypes and reinforce Orientalist preconceptions. While Disney paints portraits of cultural landscapes and attempts to traverse into the world of The Other, the question remains as to whether it is possible for the West to tell tales of a Non-White civilisation, without all the trappings of stereotypes and exoticism. Can a Media Giant like Disney truly showcase different cultures, without insinuating Western Supremacy over them all? Can they truly paint with all the colours of The Wind?

Thursday, September 19, 2019

Medieval Torture :: essays research papers

Torture is defined as in law, infliction of severe bodily pain either as punishment, or to force a person to confess to a crime, or to give evidence in a judicial proceeding. In the middle of ancient people torture has been used as a means of suffering and to punish captured enemies. It involves using instruments to force evidence from unwilling witnesses. In ancient Athens, slaves were always examined by torture, and for this reason their evidence was actually considered more valuable than a freemen. A free Athenian could not be examined by this method but torture may have been used rarely in executing criminals. Under the Roman Republic only slaves could be legally tortured and as a general rule they could not be tortured to begin the responsibility of their master. A lot of methods were used to torture people. And I am going to introduce all the methods possible. In medieval times punishment was often as cruel as the crimes. The people, who tortured sinners, used such a method called breaking with the wheel, the head crusher, or even the guillotine. The sinners would sometimes get hung. The rope that went around the sinners’ neck was called the noose. They hung sinners in gallows. They also used a hanging cage. They also made sinners sit in spiked chairs. The Iron Maiden was an example of one of these. Pressing was one of the tortures they used. Breaking with the wheel was another torture. Finger pillories and thumb cuffs were used. Although the whip left marks, it wasn’t as brutal. People often got whipped 15 to 20 times. They removed body parts quite a lot. The guillotine was used to remove heads. The headsman’s sword did the same thing as the guillotine. They also used a saw to remove arms, legs, and so many other body parts. The rack was used to stretch people out. It was the most popular instrument. They beat peo ple to death and burnt people at the stake. They also used the head crusher. Now I will tell you how these methods were used. They hung people by putting their head through a rope, then taking the floor out from under them. In the hanging cage, they locked someone in a cage and just either let them die of hunger, or rot. The spiked chairs were just chairs full of spikes that you were locked in until you speak up. Medieval Torture :: essays research papers Torture is defined as in law, infliction of severe bodily pain either as punishment, or to force a person to confess to a crime, or to give evidence in a judicial proceeding. In the middle of ancient people torture has been used as a means of suffering and to punish captured enemies. It involves using instruments to force evidence from unwilling witnesses. In ancient Athens, slaves were always examined by torture, and for this reason their evidence was actually considered more valuable than a freemen. A free Athenian could not be examined by this method but torture may have been used rarely in executing criminals. Under the Roman Republic only slaves could be legally tortured and as a general rule they could not be tortured to begin the responsibility of their master. A lot of methods were used to torture people. And I am going to introduce all the methods possible. In medieval times punishment was often as cruel as the crimes. The people, who tortured sinners, used such a method called breaking with the wheel, the head crusher, or even the guillotine. The sinners would sometimes get hung. The rope that went around the sinners’ neck was called the noose. They hung sinners in gallows. They also used a hanging cage. They also made sinners sit in spiked chairs. The Iron Maiden was an example of one of these. Pressing was one of the tortures they used. Breaking with the wheel was another torture. Finger pillories and thumb cuffs were used. Although the whip left marks, it wasn’t as brutal. People often got whipped 15 to 20 times. They removed body parts quite a lot. The guillotine was used to remove heads. The headsman’s sword did the same thing as the guillotine. They also used a saw to remove arms, legs, and so many other body parts. The rack was used to stretch people out. It was the most popular instrument. They beat peo ple to death and burnt people at the stake. They also used the head crusher. Now I will tell you how these methods were used. They hung people by putting their head through a rope, then taking the floor out from under them. In the hanging cage, they locked someone in a cage and just either let them die of hunger, or rot. The spiked chairs were just chairs full of spikes that you were locked in until you speak up.

Wednesday, September 18, 2019

Good vs. Evil in John Gardners Grendel :: Grendel Essays

Good vs. Evil in John Gardner's Grendel John Gardner's novel Grendel gives the reader a new perspective on the classic "good vs. Evil" plot. From the start of the book the reader can tell that there is something very unique about the narrator. It is evident that the narrator is a very observant being that can express himself in a very poetic manner. The story is one the reader has most likely seen before, the battle between the glorious thanes and the "evil" beast. In this case, however, the "beast" is the eyes and ears of the reader. This, of course, forces the reader to analyze situations in the book in the same way that Grendel does. By using this viewpoint, the author allows his readers to see the other side of the coin. Therefore, throughout the course of the novel the reader is able to understand how important Grendel is in defining the humans. Grendel's first encounter with the human beings that he literally defines is not a pleasant one. After accidentally trapping himself in a tree he is discovered by a group of thanes out on patrol. Grendel expresses absolutely no hostile intentions towards these "ridiculous" (ch.2, pp.24) creatures that "moved by clicks." (ch.2, pp.24) The thanes do not understand what Grendel is and are very uneasy about the whole situation. Like animals they are frightened of anything that is different from what they are used to. When Grendel attempts to communicate they show their ignorance and simple-mindedness. Instead of taking the time to understand the anomaly in their world they panic and decide to destroy it. Without being able to view the story from Grendel's point of view the reader might assume that the humans had every right to attack. Another example of the same type of simple-mindedness is their second premature attack on Grendel. After hearing the shaper's words Grendel weeps, "'Mercy! Peac e!'"(ch.4, pp.50) in the hopes of salvation from the god of these men. The men, in a drunken state, merely misunderstand Grendel's intentions and attack him once again. Instead of killing the men, which would have been an easy task for the giant, Grendel escapes into the night. This action alone defines the men as the "beasts" and Grendel as the victim.

Tuesday, September 17, 2019

How cultures use food Essay

1. Outline the way different cultures use the value food? Out of the many different cultures present throughout the world, all value food in most similar ways. Most similarities can be struck between the availability of foods within their regions, specifically enviromental and seasonal ripening in the spring period. Food has become plentiful in Western civilisations over the past few decades, , due to the advances in agriculture allowing maximum growth and larger yields in the shortest amount of time (Chemgeneration 2011). This has also introduced interest into controversial genetically modified foods and the use of hybrid varieties of plants that have more desirable qualities. An example of this is Maize and certain potatoes that secrete a pesticide from the plant to ward of pests and insects, thus removing the need to use pesticides and chemicals (Chemgeneration 2011). Dr Rosalie McCauley (Development Office Department of Agriculture and Food WA, p1), obtained results that genetically modified foods haves been more increasingly used as th e use of farmland increases exponentially at over 6% per year, seeing some 170.3 million hectares of GM foods being grown. In western society, there are a significant percentage of people either being overweight or obese, even Australia that has a population of approx 22 million (Australian Bureau of Statistics p1), with over 60% is considered over weight (ABS 2012, Australian Bureau of Statistics). Most overweight or obese individuals have and unhealthy relationship with food and it was theorised by Dr Carole Hungerford (Good Health in 21st Century) it can be considered ‘an addiction’. There is speculation as to why western society has such an addiction foods such as bread and milk, as we are the only species that drinks milk after weaning, especially that of another animal. Clinical studies and Medical Publications released by Dr J.L. Fortuna (PUBMED, 2010, p1) found clinical similarities for binge eating to that of drug dependences seeing a similar release of serotonin as with other drug dependencies. Though obesity is a prevalent condition around the world, numerous countries do not have the same obesity rates as western culture, some of this is likely to result in the way food is perceived by other cultures. Comparatively, in some cultures around the world, it is part of their culture to abstain from food for a short period of time. A more popularly known fasti ng is the Islamic undertaking of Ramadan where they fast during day light hours (Huda, 2009). Though in western cultures, people have a dislike to feel hungry, and can feel like they have fasted if they miss morning tea during a busy day at work. Numerous cultures throughout history have also used food as offering to their gods or deities to pray for health, or future harvests rain. Egyptian Pharaohs would be entombed with vast pots of food and spices to be used on their journey to the heavens. Some traditional practices continue even today such as the Korean Charye used to honour families ancestors, where special foods are prepared to during the Chuesoerk Ceremonies. The Chuesoerk (Korea.net, 2010) is a three day holiday to celebrate the good harvest received during the spring of that year. These cultural and religious uses for food are worldwide, and often not too distant from Christian practices of thanksgiving celebrated during the Christmas period. In conclusion, all cultures, no matter how distant or unique, have significant celebrations, events or relationships with a large role involving the use or lack of foods. The use of food to bring together communities and families is not dissimilar in almost all countries and demographics on earth; however the individuals use or overuse is not always healthy. References: 1. The Chemical Generation 2001, Viewed 14 January 2014 2. The Chemical Generation 2001, Viewed 14 January 2014 3. Dr Rosalie McCauley, Department of Agriculture and Food, WA, viewed 10 January 2014 4. ABS (2012) Australian health survey: First results, 2011–12. ABS cat. no. 4364.0.55.001. Canberra: Australian Bureau of Statistics. Viewed 14 January 2014 5. Aust Government, National Health and Medical Research Council. Viewed 10 January 2014 6. Hungerford, Dr Carole, 2008, Good health in the 21st century, Revised Edition, Scribe, Victoria. 7. Fortuna, J. Department of Health Science, CALIFORNIA STATE UNIVERSITY, viewed 10 January 2014 8. Huda, About.com, 2009. Viewed 15 January 2014 9. Korea.net, 2010, viewed 11 January 2014 2. What general concepts guide the present western diet? The current concepts of the western diet are based in the influence of proteins, carbohydrates, fats and vitamins and minerals (Whitney and Rolfes, 2013). Although we have come a long way with the introduction of multiculturalism some decades ago, for many western diet is still based around the proteins consisting of meats, predominantly red meat and chicken, carbohydrates with starchy root vegetables. This is often referred to as the ‘meat and three veg’ diet and the previous generations would have grown up with this as their diet staples as they where the majority of foods available for purchase or even grown themselves. With exception to the last 200 years, mankind has been involved in the seasonal use of foods and their diets where restricted by what was available at those times. Today there are vast changes in the way foods are produced to permit year round availability and the creation of food products that have previously been unavailable. Researchers at Bates Collage (Lewiston, ME, USA, 2013) believe that in the last 150 years since the invention of stones mills, the refining process of grain to create white flour, is now a consistent staple within the western diet. It was noted that this is a considerable source of carbohydrates and the cultures that had not encountered this food type previously began to show Heart Disease, Type 2 diabetes and stroke. These are all ailments that had been previously unseen in those areas. Additionally, the belief of receiving good value for money has become one of the most influential concepts and reasoning behind the purchase of processed food in recent times. The perception to receive the best meal, to be filling, quickly and well priced has seen the fast food chain market turn into a billion dollar industry (B.A. Swinburne, 2004). Anna Hodgekiss (U.S. daily Mail editor) explains that the over indulgence of these highly fatty foods have been  linked to short life spans and arrays of health problems. Even with the warnings and proven heath problems that arise, some families can become dependent on foods that are considered â€Å"value for money†. In conclusion, the general concepts to achieve the main food groups are relevant and understood but poorly enacted. The ease and availability of cheap fast food and highly refined products, that arrive ready to eat, are becoming preferential over the more time consuming cooking of foods from the local supermarket. References: 1. Whitney, E and Rolfes, S. Understanding Nutrition 13th Edition, 2013, Wadsworth USA 2. BATES Collage 2014, 2 Andrews Road Lewiston, ME 04240. Viewed 14 January 2014 3. Online book extract B.A. Swinburne, Public Health Nutrition, Chap 7, pp132 (p10). Viewed 14 January 2014 4. Hodgekiss, Anna, U.S. Daily Mail, viewed 14 January 2014 3. Discuss the comparative issues between man and nature? Nature is the world surrounding us, and it is the term we use to describe anything that happens which is out of our control. Such as natural disasters like cyclones, floods and drought. So considering this nature can not only be seen as a friend, but also as an enemy. Man desires to control nature by synthetic, mechanic and industrial plans. Synthetic and Natural medicines desire the same outcomes, of long life and good heath, but the methods to achieve it could not be any more different. Whether it is derived by numerous chemical processes or used in the original form it is found, nature made and manmade are vastly different especially when it comes to health and healing. Some cultures rely almost completely on nature to provide their basic needs such as water, food, shelter and even medicine. Though considered bland and not in line with the â€Å"perfect diet† (Health Schools Australia notes), the health benefits and improved health conditions are  achieved without the use of synthetic medicine, where as Western Diet, requires supplement by manmade medicines. This reliance on the local flora and fauna to provide all essentials and life improving aspects is not a new belief and is understood worldwide, but has been partially replaced by Western perception of that health can only be achieved by Pharmaceutical (Crigger NJ). The perception that health and food are separate and not interrelated because ‘man’ has created medicines that are better than those extracted from the ‘nature’ like Tibetans and non western cultures. In contrast, Western society has adopted that the scientific basis behind the synthetic production of therapeutic medicines is the only medical way to treat disease and illness. Today, it appears the practice of non synthetic medicinal applications is mostly centric to non western cultures. The â€Å"Perfect Diet’’ is deemed as a one shoe fits all remedy for the correct eating and dietary requirements for modern people. Where if we look at the diets of other cultures, such as the Hunza diet or Mediterranean Diet, where the majority of the population has a life expectancy significantly higher than that of the Western counterparts may have something to do with the foods that differ to that of the â€Å"Perfect Western Diet†(Diet Choices, 2014 and Trichopoula, A). One key reason is believed to be the Hunza population in the Himalayas consume more than 200% (Dainca Collins, 2011) of the B17 (also known as Amygdalan) than their western counter parts. This is likely due to the Hunza eating the seeds of all fruits, which is something that is often discarded within western society. Christina Larner (Body and Soul) has identified that Apricot se eds contain the largest concentrations of B17, and has been used a cancer treatment in modern times. However the same seeds are alleged to have caused Cyanidic acid when consumed to excessive quantities, but cases of cyanide toxicity are rare (Christina Larner). In conclusion, man created medicines for health and longevity are proven to be available in the natural world around us. Public perception provides the strongest reasons why man made pharmaceuticals are the main stream choice for western society, where as the isolated communities use the world around them to treat their ailments. 1.Whitney, E and Rolfes, S. Understanding Nutrition 13th Edition, 2013, Wadsworth USA 2.Crigger, N.J. 2009, PUBMED, US National Library of Medicine, viewed 14 January 2014 3.Diet Choices, 2014, Diet Choices, Las Vegas NV, USA, viewed 15 January 2014 < http://dietchoices.com/diet-plans/hunza-diet/> 4.Trichopoula, A. 2000, PUBMED, US National Library of Medicine, viewed 14 January 2014 5.Dainca Collins, 2011, UNDERGROUND HEALTH REPORTER, viewed 15 January 2014 6.Larner, Christina, Body and Soul, viewed 15 January 2014 4) Diversity of foods has been a benefit to the human race? Australia’s culinary heritage has expanded greatly over the last 100 years with numerous population demographics immigrating to Australia. We have observed cultural and culinary delights flood our markets, restaurants and kitchens with sights, smells and aromas from around the world. Many years ago these would have been deemed exotic and bizarre, but are now considered almost staple additions to the average household pantry. Fifty years ago, within our Grandmothers pantry, our available food selections were significantly limited in spices and rare/exotic foods that are now considered normal place. Meat and three veg meals of starchy root vegetables and heavy protein meats where the staple of the diet during those times. It is argued (Potatoes SA) that these staples popularity on Australian kitchen tables where due to the European based settlers focusing on farming practices for this produce over the last 100 years. Pliner and Hoden (cit. Evaluation of food choice behaviours, p 20) stated it was more to do with the neophobic attitude towards foreign foods due to the â€Å"unfamiliarity of foods† that limited the adventurous mindset to the evolving culinary scene. In either case, only since World War 2 did the appearance of multicultural foods and diets start to intermix. One of the most popular entries into our diets is the highly regarded Mediterranean diet consisting of uncooked fresh whole vegetables, whole grains and some fish and seafood but minimal meat. That compared to the past diets of root based vegetables that where often boiled or baked, and argued to lose most of its natural vitamins and minerals during the cooking process, especially seen with water soluble vitamins (Better Health Channel). The high use of tomatoes within the Mediterranean diet, which contain large amounts of the antioxidant lycopene and that is believed to have anti-tumour properties to relieve cancers  particularly in the prostate and multiple-myeloma (Tonia Reinhard, p44-45). Additionally, the vibrant coloured vegetables that contain high amounts of VIT A and C such as Capsicums, Spinach, green leafy vegetables. VIT A is required for vision, the immune system and as an antioxidant. Dr Carole Hungerford (Good health in 21st century, p160) identifies that night blindness is a symptom of VIT A deficiency. Even the fats used are considered healthier with the Olives and olive oil as the principle source of fat. Tonia Reinhard states that Olive oil contains the richest source of mono unsaturated fatty acids, being 77% mono-unsaturated and 14% saturated, this is attributed as to why it helps to prevent cardiovascular disease. In conclusion, the diversity of foods that have spread across the world is bring ing the many health benefits to many. As the world continues to expand and new ideas and foods are embraced, soon the healing and healthy properties of those unique diets will improve the health and well being across the globe. 1.Potatoes South Australia, 2013, Elder House, Adelaide, SA, viewed 15 January 2014 2.Online Thesis – Roininen, Katariina, 2001, Evaluation of food choice behaviour: Development and Validation of health and taste attitude scales, visited 15 January 2014 3.Better Health Channel, July 2013, Victorian Government, viewed 15 January 2014 4.Hungerford, Dr Carole, 2008, Good health in the 21st century, Revised Edition, Scribe, Victoria. 5.Reinhard, Tonia, (2010), SUPERFOODS The Healthiest Foods on the Planet, Cove Press, NSW 5) The future of nutrition In the past and even in some places still today, nutrition has not play a conscious role in conventional medicine, as the focus has and always seems to be about treating disease not the cause. Nutrition based medicine has been labelled with a stigma as ‘alternative’ or new age and not given the same attention as the newest drug on the market. Recently have we begun to see some changes within the health care system which offers clients a  natural alternative to pharmaceuticals. This has began a movement known as Integrative Medicine (OSHER, 2012), where the approach is about taking the best from conventional and alternative medicine and combining them. This combination of practices is reinforcing the tenants of prevention rather than cure, which follows the old adage that â€Å"an ounce of prevention is better than a pound of cure†. We are already seeing this revolutionary ideal take off with the emergence of integrative clinics now established in some major citi es, and where patients even seek further information from their GP on what additional alternative treatments are available for their ailments (Mike Adams, 2005). This wider social consciousness towards natural alternatives is perhaps due to the increased marketing of nutritional supplements within media (Mike Adams, 2005). These messages are making people more curious about their health and what they can do to improve it. In addition, we are seeing nutritional products such as ‘Inner Health Plus’ a pro-biotic supplement, is sometimes prescribed to patients following a course of antibiotics. This behaviour by GP’s is demonstrating a small but important step to the medical and health organisations towards the evolution of nutritional medicine. The popularity of supplements and their advertised health benefits has propelled the sale of many nutritional products, especially Omega 3 supplements derived from fish oil or krill oil (Lisa Schofield, 2013). Omega 3 that is naturally occurring within deep ocean fish species has been proven to be beneficial for arthritis suffers, for heart health, and general wellbeing (Whitney, 2013, pg 161.). Dr Hungerford (Hungerford, 2008) tells us that until recent times, animals who do not manufacture their own omega 3 would have had to eat plants which contain omega 3’s for protection against the cold and other health benefits. However, as we domesticated animals, kept them warm in barns, and fed them the food we grew; the animals did not require as much omega 3 in order to survive. This man made change is a potential reason is why fish still remains one of the best sources of omega 3, as the majority of fish that we consume are wild. (Hungerford, 2008 pg. 6-7). In summary, the stigma of nutritional based medicine is slowly being lifted as media, mainstream medicine and health care practitioners inculcate these practices into their professions. Today, more than ever, people have access to the information and products that can be utilised to improve their health, wellbeing and  diets. As the message becomes clearer and better understood, it is likely that the stigma will be removed completely and nutritionists will be given the same renowned as the doctors and medical professionals that share the same vision for long and healthy life for all. 1.Osher Centre for Integrative Medicine, University of California, 2012, CA, USA, viewed 17 Jan 2014 2.Adams, Mike, 24 July 2005, Natural News, viewed 17 Jan 2014 3.Hungerford, Dr Carole, 2008, Good health in the 21st century, Revised Edition, Scribe, Victoria 4.Schofield, Lisa, 09 Sep 2013, Nutraceuticals World, viewed 17 January 2014 5.Whitney, E and Rolfes, S. Understanding Nutrition 13th Edition, 2013, Wadsworth USA Bibliography ABS (2012) Australian health survey: First results, 2011–12. ABS cat. no. 4364.0.55.001. Canberra: Australian Bureau of Statistics. Viewed 14 January 2014 Adams, Mike, 24 July 2005, Natural News, viewed 17 Jan 2014 Aust Government, National Health and Medical Research Council. 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